解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an ever-increasing burden to an aging population. Several loci responsible for the rare, autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have facilitated the development of the amyloid cascade hypothesis...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2011.07.017
更新日期:2012-02-01 00:00:00
abstract::This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.07.015
更新日期:2012-02-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.12.005
更新日期:2011-12-16 00:00:00
abstract::Macrophages located in airways and the alveolar space are continually exposed to different signals from the respiratory mucosa. In this respect, epithelial cells represent an important source of cytokines and mediators modulating the state of activation and/or differentiation of mononuclear phagocytes. Many of the pro...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.04.009
更新日期:2011-10-01 00:00:00
abstract::Infectious bursal disesase is a highly contagious, wide spread immunosuppressive chicken disease caused by the Infectious Bursal Disease Virus (IBDV). IBDV is a two segmented double-strand RNA virus, member of the Birnaviridae family. In order to study the interaction between IBDV and the immune system, chickens were ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.03.003
更新日期:2011-09-01 00:00:00
abstract::Defects in macrophage function have been implicated in the establishment of Crohn's disease (CD). However, the response of macrophages from CD patients to live bacteria, particularly Mycobacterium avium subsp. paratuberculosis (MAP), has not been addressed. Considering MAP has long been associated to CD, our objective...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.01.002
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.02.003
更新日期:2011-08-01 00:00:00
abstract::This study tested the hypothesis that prolonged severe hypoxia during monocyte to macrophage differentiation results in macrophages with a pattern of gene expression and phenotype distinct from those maturing in normal oxygen levels. Macrophages accumulate in hypoxic and anoxic areas within pathological sites such as ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.12.005
更新日期:2011-07-01 00:00:00
abstract::The activating C-type lectin-like receptor NKG2D, which is expressed by mouse NK cells and activated CD8 T cells, was previously demonstrated to be involved in tumor rejection and as a defense mechanism against viral and bacterial infections. Because CD8 T cells are important for protective immune responses during chr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.010
更新日期:2011-05-01 00:00:00
abstract:CONTEXT:The PDS gene (SLC26A4) is responsible for Pendred syndrome (PS). Genetic analysis of PDS using Tunisian samples showed evidence for linkage and association with autoimmune thyroid diseases (AITD) emergence. In addition, the PDS gene product, pendrin, was recently identified as a novel autoantigen in Graves' dis...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.015
更新日期:2011-05-01 00:00:00
abstract::Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.007
更新日期:2011-05-01 00:00:00
abstract::CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.016
更新日期:2011-05-01 00:00:00
abstract::The antimicrobial peptide human β-defensin-3 (hBD-3) is produced by epidermal keratinocytes, and exhibits broad killing activity against bacteria or fungi. Prostaglandin D(2) enhances hBD-3 production in human keratinocytes by stimulating a transcription factor, activator protein-1 via chemoattractant receptor-homolog...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.08.008
更新日期:2011-04-01 00:00:00
abstract::Recent studies have suggested that odontoblasts are involved in the dental pulp immune response to oral pathogens that invade human dentin during the caries process. How odontoblasts regulate the early inflammatory and immune pulp response to Gram-positive bacteria, which predominate in shallow and moderate dentin car...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.08.006
更新日期:2011-04-01 00:00:00
abstract::Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood, protecting early sexual initiation, should be considered as strategies to vaccination against HIV. The HIV-1 GAG protein as a chimera with the lysosome-associated membrane protein (LAMP/gag), encoded by a DNA vaccine, is targeted to...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.08.007
更新日期:2011-04-01 00:00:00
abstract::Investigating the expression of lipoteichoic acid (LTA) from Listeria monocytogenes, we found two distinct structural variants of LTA (LTA1 and LTA2) using NMR and MS technology. While both LTA consisted of a poly-glycerophosphate backbone (differing in length) bound via a disaccharide to a diacyl-glycerol moiety, one...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.03.008
更新日期:2011-01-01 00:00:00
abstract::IgE-mediated food allergies are an important cause of life-threatening hypersensitivity reactions. Orally administered peanut antigens mixed with the mucosal adjuvant cholera toxin (CT) induce a strong peanut extract (PE)-specific serum IgE response that is correlated with T-helper type 1 (Th1) and type 2 (Th2)-like T...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.02.004
更新日期:2010-12-01 00:00:00
abstract::Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted o...
journal_title:Immunobiology
pub_type: 杂志文章,病人教育讲义,评审
doi:10.1016/j.imbio.2010.05.027
更新日期:2010-09-01 00:00:00
abstract::It is commonly accepted that dendritic cells (DCs) play a pivotal role in the induction of adaptive T cell-mediated immune responses. The clonal expansion of antigen-specific T cells within secondary lymphoid organs reflects the efficiency of antigen processing and presentation by DCs. Consequently, the quantification...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.05.017
更新日期:2010-09-01 00:00:00
abstract::Dendritic cells capture and process antigen and present it to T lymphocytes in the lymphoid organs. Dendritic cells of the skin, including epidermal Langerhans cells, langerin(+) and langerin(negative) dermal dendritic cells are ideally positioned to take up pathogens that enter the body through the skin or vaccines t...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.05.014
更新日期:2010-09-01 00:00:00
abstract::In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2009.10.003
更新日期:2010-07-01 00:00:00
abstract::Gaucher disease (GD) is associated with upregulation of CD1d and MHC-class II expression by monocytes. While the physiological impact of CD1d upregulation remains uncertain, it has been proposed that MHC-class II upregulation is associated with inflammation. Hereby, we show that the decrease in MHC-class II expression...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.07.002
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The soluble form of the haptoglobin-hemoglobin (Hp-Hb) scavenger receptor (sCD163) is a specific plasma/serum marker for macrophage activity. Here, we have characterized molecular forms in serum and investigated a role of sCD163 as a binder of Hp-Hb complexes. METHODS:The sCD163 species in serum (from 50 he...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.05.003
更新日期:2010-05-01 00:00:00
abstract:AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.05.006
更新日期:2010-04-01 00:00:00
abstract::Soluble MHC antigens are detected in body fluids but their role and origin are still unclear. This study examined whether serum IA antigens, isolated from BALB/c mice (sIA(d)), could modulate the immune response. Specific purification procedures isolated intact IA molecules, which were thereafter applied to functional...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.04.005
更新日期:2010-03-01 00:00:00
abstract::Antibody-mediated elimination of foreign antigens contributes to immune protection from viral infection. We have generated phycoerythrin-conjugated HIV-1 Gag/p24 and influenza virus nucleoprotein tetramers for flow cytometric analysis of blood cell populations involved in antibody-mediated immunity. We show that in th...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.02.004
更新日期:2010-03-01 00:00:00
abstract::High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Attempts to reverse suppression by treatment with pro-inflammatory cytokines revealed that IL-6 improved the T cell response to Mls and the pro-he...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.01.015
更新日期:2010-01-01 00:00:00
abstract::The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.07.030
更新日期:2009-01-01 00:00:00
abstract::Interleukin-1beta (IL-1beta) is a potent proinflammatory cytokine that initiates and amplifies a wide variety of effects associated with innate immunity and host responses to microbial invasion and tissue injury. Production and release of IL-1beta are stimulated by either pathogen-associated molecular pattern molecule...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2008.11.007
更新日期:2009-01-01 00:00:00
abstract::Recent evidences suggest a significant role of Plasmacytoid dendritic cells (PDC) role in the pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing PDC on fixed tissues, we investigated the occ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.06.013
更新日期:2009-01-01 00:00:00
abstract::OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.10.008
更新日期:2009-01-01 00:00:00
abstract::Anti-anaemic drug ferric-sorbitol citrate showed immunomodulatory effects, activating NF-kappaB in peritoneal macrophages, which consequently secrete tumour necrosis factor-alpha (TNF-alpha). TNF-alpha activates NF-kappaB in spleen cells. The aim of this study was to investigate the effect of iron polyisomaltosate, an...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.07.005
更新日期:2009-01-01 00:00:00
abstract::Heat shock proteins (Hsps) or stress proteins are highly conserved molecules and expressed in all cell types under stressful conditions like heat, cold, hypoxia and infections. The objective of the present study was to determine the effect of dengue virus infection on relative expression of stress proteins and their r...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.11.010
更新日期:2009-01-01 00:00:00
abstract::The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. All family members have a single Ig-V like domain and they share a common evolutionary pathway. At least one member of the family ha...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2009.06.004
更新日期:2009-01-01 00:00:00
abstract::Equine dendritic cells (eqDC) can be generated from peripheral blood monocytes by propagation in GM-CSF and IL-4. Despite similarities with the generation of human DC, we found significant improvements for eqDC generation and functional influences on eqDC maturation. The fractionation of peripheral blood mononuclear c...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.07.024
更新日期:2008-01-01 00:00:00
abstract::Dendritic cells (DCs) play a key role in the orchestration of the immune system by virtue of their capacity to control both immunity and tolerance induction. The functions of DCs depend on the subset as well as their location and activation state. A number of in vitro protocols, developed to recapitulate DC generation...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2008.07.017
更新日期:2008-01-01 00:00:00
abstract::P2X7 receptor activation is involved in a number of pro-inflammatory responses in macrophages and other immune cells. Their expression can be positively modulated with lipopolysaccharide (LPS) and TNFalpha, reinforcing their role during inflammation. We investigated the effect of substances capable of recruiting macro...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2007.11.006
更新日期:2008-01-01 00:00:00
abstract::Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration,...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2007.10.003
更新日期:2008-01-01 00:00:00
abstract::The nematode Caenorhabditis elegans has become an important model for the study of innate immunity. Its immune system is based on several signaling cascades, including a Toll-like receptor, three mitogen-activated protein kinases (MAPK), one transforming growth factor-beta (TGF-beta), the insulin-like receptor (ILR), ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2007.12.004
更新日期:2008-01-01 00:00:00
abstract::The lymphotoxin beta receptor (LTbetaR) mediates crucial signals in host defense against intracellular bacteria and viruses. Mice deficient in LTbetaR readily succumb to infections with Listeria monocytogenes, Mycobacterium tuberculosis and murine cytomegalovirus (mCMV). LTbetaR has been shown to be important for the ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2007.10.011
更新日期:2008-01-01 00:00:00